Berthiaume is a surname. Notable people with the surname include:
Daniel Berthiaume (born 1966), Canadian retired professional ice hockey goaltenderDaniel Berthiaume (singer, songwriter), born in Montreal, CanadaRaymond Berthiaume (born 1931), jazz singer, musician, producer and composer from Québec, CanadaRené Berthiaume (born 1952), Canadian politician, who was elected mayor of Hawkesbury, Ontario in the 2010 municipal electionSteve Berthiaume (born 1965), Current Arizona Diamondbacks announcer and a former sportscaster for SportsNet New York (SNY) and ESPNTrefflé Berthiaume (1848–1915), Canadian typographer, newspaperman and politician