Benzyl 2 methyl hydroxybutyrate dehydrogenase

In enzymology, a benzyl-2-methyl-hydroxybutyrate dehydrogenase (EC 1.1.1.217) is an enzyme that catalyzes the chemical reaction

benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP⁺ ⇌ benzyl 2-methyl-3-oxobutanoate + NADPH + H⁺

Thus, the two substrates of this enzyme are benzyl (2R,3S)-2-methyl-3-hydroxybutanoate and NADP⁺, whereas its 3 products are benzyl 2-methyl-3-oxobutanoate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is benzyl-(2R,3S)-2-methyl-3-hydroxybutanoate:NADP⁺ 3-oxidoreductase. This enzyme is also called benzyl 2-methyl-3-hydroxybutyrate dehydrogenase.