Baldacchino is a surname. Notable people with the surname include:
Clifford Gatt Baldacchino (born 1988), Maltese footballer
Francis Baldacchino (1937–2009), Kenyan Roman Catholic bishop
Godfrey Baldacchino (born 1960), Maltese-Canadian social scientist
Joseph Baldacchino (1894–1974), Maltese archaeologist
Peter Baldacchino (born 1960), Maltese-born American Roman Catholic bishop
Ryan Baldacchino (born 1981), English footballer