Bacigalupo is an Italian surname. Notable people with the surname include:
Giuseppe Bacigalupo (1744–1821), Italian painterManlio Bacigalupo (1908–1977), Italian association football goalkeeperManuel Bacigalupo (1916–1965), Peruvian cyclistMassimo Bacigalupo (born 1947), Italian filmmaker, translator, essayist and literary criticNélida María Bacigalupo (born 1924), Argentine botanistRenato Bacigalupo (1908–1979), Italian Olympic swimmerRolando Bacigalupo (1914–?), Peruvian Olympic basketball playerScott Bacigalupo, American lacrosse goaltenderValerio Bacigalupo (1924–1949), Italian association football goalkeeper, brother of Manlio