Samiksha Jaiswal (Editor)

BCL3

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Species
  
Entrez
  
602

Human
  
Ensembl
  
ENSG00000069399

BCL3 httpsuploadwikimediaorgwikipediacommonsthu

Aliases
  
BCL3, BCL4, D19S37, B-cell CLL/lymphoma 3

External IDs
  
MGI: 88140 HomoloGene: 81738 GeneCards: BCL3

B-cell lymphoma 3-encoded protein is a protein that in humans is encoded by the BCL3 gene.

This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional coactivator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B.

Like BCL2, BCL5, BCL6, BCL7A, BCL9, and BCL10, it has clinical significance in lymphoma.

Interactions

BCL3 has been shown to interact with:

References

BCL3 Wikipedia


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