Supriya Ghosh (Editor)

BCL2 like 1 (gene)

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Species
  
Human

Entrez
  
598

Human
  
Mouse

Ensembl
  
ENSG00000171552

BCL2-like 1 (gene)

Aliases
  
BCL2L1, Bcl2l1, Bcl(X)L, Bcl-XL, Bcl2l, BclX, bcl-x, bcl2-L-1, BCL-XL/S, BCLXL, BCLXS, PPP1R52, bcl-xS, BCL2L, BCLX, Bcl-X, bcl-xL, BCL2 like 1

External IDs
  
MGI: 88139 HomoloGene: 7639 GeneCards: BCL2L1

Bcl-2-like 1 or BCL2L1 is a human gene. Through alternative splicing, it encodes both of the human proteins Bcl-xL and Bcl-xS.

Contents

Function

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species (ROS) and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform (Bcl-xL) acts as an apoptotic inhibitor and the shorter form (Bcl-xS) acts as an apoptotic activator.

A LncRNA (Long non coding RNA, a RNA that acts without coding a protein) is involved with the alternative splicing between the two isoforms (BCL-XL and BCL-XS). This LncRNA is called INXS and acts as a pro-apoptotic agent, been downregulated in cancer cells.

Interactions

BCL2-like 1 (gene) has been shown to interact with:

References

BCL2-like 1 (gene) Wikipedia