Symbol B5 InterPro IPR005147 SCOP 1qq3 | Pfam PF03484 PROSITE PDOC00464 SUPERFAMILY 1qq3 | |
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In molecular biology, Domain B5 is found in phenylalanine-tRNA synthetase beta subunits. This domain has been shown to bind DNA through a winged helix-turn-helix motif. Phenylalanine-tRNA synthetase may influence common cellular processes via DNA binding, in addition to its aminoacylation function.
Function
The beta domain, in particular, B5, is required for the correct amino acid to be joined to the corresponding tRNA. Hence, the B5 domain is crucial to accurate translation. Failure to do so, results in a mutated protein which improperly folds and consequently protein function is affected.
References
B5 protein domain Wikipedia(Text) CC BY-SA