Ayton is an English surname. Notable people with the surname include:
DeAndre Ayton, basketball player
Fanny Ayton (1806 – after 1833), English opera singer
Sir Robert Ayton (1570–1638), Scottish poet
Robert Ayton (illustrator) (1915–1985), British comics artist and illustrator
Sarah Ayton (born 1980), English professional sailor
William Alexander Ayton (1816–1909), British Anglican clergyman