Avilés is a Spanish surname. Notable people with the surname include:
Caleb Avilés, former member of the boy band MDO
Gabriel de Avilés, 2nd Marquis of Avilés, governor of Chile, viceroy of Río de la Plata, and viceroy of Peru
Lucho Avilés, Uruguayan-born Argentine journalist and television presenter
Óscar Avilés (1924–2014), Peruvian musician
Pedro Avilés, Spanish writer
Pedro Menéndez de Avilés (1519-1574), first governor of Spanish Florida & governor of colonial Cuba
Ramón Avilés, Puerto Rican baseball player
Raúl Avilés, Ecuadorian footballer
René Avilés Fabila, Mexican writer
