Avetisyan (Armenian: Ավետիսյան) is an Armenian surname. Notable people with the surname include:
Arsen Avetisyan (born 1973), an Armenian football player
Erdzhanik Avetisyan (born 1969), an Armenian and Russian sport shooter
Hunan Avetisyan (1913–1943), a Soviet senior sergeant awarded the title Hero of the Soviet Union
Khachatur Avetisyan (1926–1996), an Armenian-Soviet composer
Minas Avetisyan (1928–1975), an Armenian painter
Varduhi Avetisyan (born 1986), an Armenian swimmer