EC number 4.1.1.11 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 9024-58-2 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, an aspartate 1-decarboxylase (EC 4.1.1.11) is an enzyme that catalyzes the chemical reaction
L-aspartateHence, this enzyme has one substrate, L-aspartate, and two products, beta-alanine and CO2.
This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is L-aspartate 1-carboxy-lyase (beta-alanine-forming). Other names in common use include aspartate alpha-decarboxylase, L-aspartate alpha-decarboxylase, aspartic alpha-decarboxylase, and L-aspartate 1-carboxy-lyase. This enzyme participates in alanine and aspartate metabolism and beta-alanine metabolism.
Structural studies
As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes 1AW8, 1PPY, 1PQE, 1PQF, 1PQH, 1PT0, 1PT1, 1PYQ, 1PYU, 1UHD, 1UHE, and 2C45.