Species Human Entrez 9048 | Human Mouse Ensembl ENSG00000117407 | |
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Aliases ARTN, ENOVIN, EVN, NBN, artemin External IDs OMIM: 603886 MGI: 1333791 HomoloGene: 7631 GeneCards: ARTN | ||
Artemin, also known as enovin or neublastin, is a protein that in humans is encoded by the ARTN gene.
Function
Artemin is a neurotrophic factor in the glial cell line-derived neurotrophic factor family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenerative disease. Artemin has been shown in culture to support the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor.