Arrowsmith is a surname. Notable people with the surname include:
Aaron Arrowsmith (1750–1823), English cartographer
Alf Arrowsmith (1942–2005), English footballer
Anna Arrowsmith (born 1972), under the pseudonym Anna Span, British pornographic film director and politician
Arthur Arrowsmith (1880–?), English footballer who played for Stoke City
Alex Arrowsmith (born 1982), rock musician
Cheryl Arrowsmith, Canadian structural biologist
Clive Arrowsmith, English photographer
Edmund Arrowsmith (1585–1628), Roman Catholic martyr and saint
John Arrowsmith (scholar) (1602–1659), English theologian and Master of Trinity College, Cambridge
John Arrowsmith (cartographer) (1780–1873), geographer and map publisher
Pat Arrowsmith (born 1930), British author and peace campaigner
Percy and Florence Arrowsmith, a British couple erroneously included in the Guinness Book of Records
Robert Arrowsmith (born 1952), English cricketer
Tony Arrowsmith (1887–?), English footballer who played for Grimsby Town
William Arrowsmith (1924–1992), American classicist, academic and translator