Arrowsmith is a surname. Notable people with the surname include:
Aaron Arrowsmith (1750–1823), English cartographerAlf Arrowsmith (1942–2005), English footballerAnna Arrowsmith (born 1972), under the pseudonym Anna Span, British pornographic film director and politicianArthur Arrowsmith (1880–?), English footballer who played for Stoke CityAlex Arrowsmith (born 1982), rock musicianCheryl Arrowsmith, Canadian structural biologistClive Arrowsmith, English photographerEdmund Arrowsmith (1585–1628), Roman Catholic martyr and saintJohn Arrowsmith (scholar) (1602–1659), English theologian and Master of Trinity College, CambridgeJohn Arrowsmith (cartographer) (1780–1873), geographer and map publisherPat Arrowsmith (born 1930), British author and peace campaignerPercy and Florence Arrowsmith, a British couple erroneously included in the Guinness Book of RecordsRobert Arrowsmith (born 1952), English cricketerTony Arrowsmith (1887–?), English footballer who played for Grimsby TownWilliam Arrowsmith (1924–1992), American classicist, academic and translator