Neha Patil

Arginine decarboxylase

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EC number
IntEnz  IntEnz view
ExPASy  NiceZyme view
CAS number  9024-77-5
KEGG  KEGG entry

In enzymology, an arginine decarboxylase (EC is an enzyme that catalyzes the chemical reaction

L-arginine agmatine + CO2

Hence, this enzyme has one substrate, L-arginine, and two products, agmatine and CO2.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is L-arginine carboxy-lyase (agmatine-forming). Other names in common use include SpeA, and L-arginine carboxy-lyase. This enzyme participates in urea cycle and metabolism of amino groups and glutamate metabolism. It employs one cofactor, pyridoxal phosphate.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1MT1, 1N13, 1N2M, 2NV9, and 2NVA.


Arginine decarboxylase Wikipedia

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