Species Human Entrez 358 | Human Mouse Ensembl ENSG00000240583 | |
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Aliases AQP1, AQP-CHIP, CHIP28, CO, aquaporin 1 (Colton blood group) External IDs OMIM: 107776 MGI: 103201 HomoloGene: 68051 GeneCards: AQP1 | ||
Aquaporin 1 is a protein that in humans is encoded by the AQP1 gene.
AQP1 is a widely expressed water channel, whose physiological function has been most thoroughly characterized in the kidney. It is found in the basolateral and apical plasma membranes of the proximal tubules, the descending limb of the loop of Henle, and in the descending portion of the vasa recta. Additionally, it is found in red blood cells, vascular endothelium, the gastrointestinal tract, sweat glands, and lungs.
It is not regulated by vasopressin (ADH).
Function
Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This gene encodes an aquaporin which functions as a molecular water channel protein. It is a homotetramer with 6 bilayer spanning domains and N-glycosylation sites. The protein physically resembles channel proteins and is abundant in erythrocytes and renal tubes. The gene encoding this aquaporin is a possible candidate for disorders involving imbalance in ocular fluid movement.