Trisha Shetty

Aquacobalamin reductase (NADPH)

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EC number  1.16.1.5
IntEnz  IntEnz view
ExPASy  NiceZyme view
CAS number  110777-32-7
BRENDA  BRENDA entry
KEGG  KEGG entry

Aquacobalamin reductase (NADPH) (EC 1.16.1.5) is an enzyme that catalyzes the chemical reaction

2 cob(II)alamin + NADP+ 2 aquacob(III)alamin + NADPH + H+

Thus, the two substrates of this enzyme are cob(II)alamin and nicotinamide adenine dinucleotide phosphate ion, whereas its 3 products are aquacob(III)alamin, nicotinamide adenine dinucleotide phosphate, and hydrogen ion.

This enzyme belongs to the family of oxidoreductases, specifically those oxidizing metal ion with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cob(II)alamin:NADP+ oxidoreductase. Other names in common use include aquacobalamin (reduced nicotinamide adenine dinucleotide phosphate), reductase, NADPH-linked aquacobalamin reductase, and NADPH2:aquacob(III)alamin oxidoreductase. This enzyme participates in porphyrin and chlorophyll metabolism. It employs one cofactor, FAD.

References

Aquacobalamin reductase (NADPH) Wikipedia


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