Jamal al-Din Muhammad ibn Muhammad Aqsara'i (died 1379), also written al-Aqsara'i, was a 14th-century Persian or Turkish physician.
He is known for his commentary on the Mujiz, which was an epitome made in the 13th century by Ibn al-Nafis of The Canon of Medicine of Avicenna.
Al-Aqsara'i studied medicine with his father, under whose tutelage he first read the Mujiz. Thereafter he studied The Canon of Medicine itself, as well as the Hawi by Razi and the Complete Book on Medicine by al-Majusi, as well as the medical writings of Najib al-Din al-Samarqandi. He employed these other treatises in his commentary on the Mujiz, and he titled his commentary "The Key to the Mujiz" (Hall al-Mujiz).
He died in 1379.