Species Human Entrez 344 | Human Mouse Ensembl ENSG00000224916 | |
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Aliases APOC2, APO-CII, APOC-II, apolipoprotein C2 External IDs OMIM: 608083 MGI: 88054 HomoloGene: 47928 GeneCards: APOC2 | ||
Apolipoprotein C2 or apolipoprotein C-II is a protein that in humans is encoded by the APOC2 gene.
The protein encoded by this gene is secreted in plasma where it is a component of very low density lipoproteins and chylomicrons. This protein activates the enzyme lipoprotein lipase in capillaries, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by xanthomas, pancreatitis, and hepatosplenomegaly, but no increased risk for atherosclerosis. Lab tests will show elevated blood levels of triglycerides, cholesterol, and chylomicrons
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles.
References
Apolipoprotein C2 Wikipedia(Text) CC BY-SA