Antonio Ferrante Gonzaga (9 December 1687 – 16 April 1729) was Duke of Guastalla.
He was the son of Vincenzo Gonzaga, Duke of Guastalla and Maria Vittoria Gonzaga.
His sister was Eleonora Luisa Gonzaga, sister in law to Cosimo III de' Medici, Grand Duke of Tuscany. He succeeded his father in 1714.
He was engaged to Maria Karolina Sobieska, grand daughter of John III Sobieski but Maria Karolina (known as Charlotte) refused.
He married first with Margherita Cesarini, and remarried on 23 February 1727 in Darmstadt with Landgravine Theodora of Hesse-Darmstadt (6 February 1706 – 23 January 1784), daughter of Philip of Hesse-Darmstadt, granddaughter of Louis VI, Landgrave of Hesse-Darmstadt.
These marriages remained childless.
Antonio Ferrante was burned alive in an accident in Guastalla.
After his death, the Duchy went to his younger brother Giuseppe Gonzaga.