Antonelli is an Italian surname. Notable people with the surname include:
Andrea Antonelli (1988–2013), Italian motorcycle racerFilippo Antonelli (born 1978), Italian football playerAlessandro Antonelli (1798–1888), Italian architectCosimo Antonelli (1925–2014), Italian water polo playerDominic A. Antonelli (born 1967), NASA astronautEnnio Antonelli (born 1936), Roman Catholic CardinalGiacomo Antonelli (1806–1876), 19th-century lay cardinalJohnny Antonelli (born 1930), baseball playerJuan Bautista Antonelli Italian engineer of the 15th centuryKathleen Antonelli (1921–2006), ENIAC programmerLaura Antonelli (1941–2015), former Italian film actressLeonardo Antonelli (1730–1811), Italian CardinalLou Antonelli (born 1957), American writerLuca Antonelli (born 1987), Italian football playerMarco Antonelli, Italian racing driverMatt Antonelli (born 1985), baseball playerSevero Antonelli (1907–1995), Italian-American photographerDomenico Antonelli (1857–1943), Manufacturer of Ice Cream Cones and Wafers at International Wafer Company