Antonelli is an Italian surname. Notable people with the surname include:
Andrea Antonelli (1988–2013), Italian motorcycle racer
Filippo Antonelli (born 1978), Italian football player
Alessandro Antonelli (1798–1888), Italian architect
Cosimo Antonelli (1925–2014), Italian water polo player
Dominic A. Antonelli (born 1967), NASA astronaut
Ennio Antonelli (born 1936), Roman Catholic Cardinal
Giacomo Antonelli (1806–1876), 19th-century lay cardinal
Johnny Antonelli (born 1930), baseball player
Juan Bautista Antonelli Italian engineer of the 15th century
Kathleen Antonelli (1921–2006), ENIAC programmer
Laura Antonelli (1941–2015), former Italian film actress
Leonardo Antonelli (1730–1811), Italian Cardinal
Lou Antonelli (born 1957), American writer
Luca Antonelli (born 1987), Italian football player
Marco Antonelli, Italian racing driver
Matt Antonelli (born 1985), baseball player
Severo Antonelli (1907–1995), Italian-American photographer
Domenico Antonelli (1857–1943), Manufacturer of Ice Cream Cones and Wafers at International Wafer Company