Kalpana Kalpana

Ansofaxine

Updated on
Share on FacebookTweet on TwitterShare on LinkedIn
Routes of administration  Oral
ChemSpider  13114670
3D model (Jmol)  Interactive image
ATC code  None
Formula  C24H31NO3
Molar mass  381.508 g/mol
Ansofaxine httpsuploadwikimediaorgwikipediacommonsthu

Ansofaxine hydrochloride (INN) (former developmental code names LY03005, LPM570065), also known as 4-methylbenzoate desvenlafaxine hydrochloride, is a serotonin-norepinephrine-dopamine reuptake inhibitor that is under development by Luye Pharma Group for the treatment of major depressive disorder. It is described as an SNDRI and prodrug to desvenlafaxine. However, unlike desvenlafaxine, which has in vitro IC50 values of 53 nM and 538 nM for inhibition of serotonin and norepinephrine reuptake, respectively, ansofaxine has respective in vitro IC50 values of 723 nM, 763 nM, and 491 nM for serotonin, norepinephrine, and dopamine reuptake inhibition. As of March 2015, the drug is in phase I clinical trials.

References

Ansofaxine Wikipedia


Similar Topics
Sherrybaby
Abu al Baraa el Azdi
Douglas Reeman
Topics