Annapolis was laid out in 1871, and according to tradition, named after Anna Allen, the wife of a railroad official. The name is also said to be a transfer from Annapolis, Maryland. A post office called Annapolis has been in operation since 1871.
Annapolis was destroyed by the Great Tri-State Tornado of 1925.
Annapolis is located at 37°21′36″N 90°41′50″W (37.359993, -90.697123).
According to the United States Census Bureau, the city has a total area of 0.37 square miles (0.96 km2), of which 0.36 square miles (0.93 km2) is land and 0.01 square miles (0.03 km2) is water.
As of the census of 2010, there were 345 people, 155 households, and 85 families residing in the city. The population density was 958.3 inhabitants per square mile (370.0/km2). There were 171 housing units at an average density of 475.0 per square mile (183.4/km2). The racial makeup of the city was 99.13% White, 0.29% Native American, 0.29% from other races, and 0.29% from two or more races. Hispanic or Latino of any race were 0.87% of the population.
There were 155 households of which 30.3% had children under the age of 18 living with them, 34.8% were married couples living together, 14.2% had a female householder with no husband present, 5.8% had a male householder with no wife present, and 45.2% were non-families. 40.0% of all households were made up of individuals and 13.6% had someone living alone who was 65 years of age or older. The average household size was 2.15 and the average family size was 2.88.
The median age in the city was 40.2 years. 24.9% of residents were under the age of 18; 8.4% were between the ages of 18 and 24; 23.4% were from 25 to 44; 24.3% were from 45 to 64; and 18.8% were 65 years of age or older. The gender makeup of the city was 45.8% male and 54.2% female.
As of the census of 2000, there were 310 people, 136 households, and 84 families residing in the city. The population density was 815.5 people per square mile (315.0/km²). There were 161 housing units at an average density of 423.5 per square mile (163.6/km²). The racial makeup of the city was 99.35% White, 0.32% Native American, and 0.32% from two or more races.
There were 136 households out of which 29.4% had children under the age of 18 living with them, 43.4% were married couples living together, 16.2% had a female householder with no husband present, and 38.2% were non-families. 38.2% of all households were made up of individuals and 20.6% had someone living alone who was 65 years of age or older. The average household size was 2.13 and the average family size was 2.79.
In the city the population was spread out with 22.6% under the age of 18, 8.7% from 18 to 24, 27.4% from 25 to 44, 16.8% from 45 to 64, and 24.5% who were 65 years of age or older. The median age was 39 years. For every 100 females there were 75.1 males. For every 100 females age 18 and over, there were 71.4 males.
The median income for a household in the city was $28,389, and the median income for a family was $24,464. Males had a median income of $25,019 versus $12,746 for females. The per capita income for the city was $10,015. About 11.2% of families and 17.4.1% of the population were below the poverty line, including 9.8% of those under age 18 and 27.0% of those age 65 or over.
Annapolis is home to South Iron High School, which hosts the South Iron Panthers, among the most successful basketball teams in Missouri history. Annapolis is also home to a city library.
Annapolis is home to an event called "Freedom Fest." The festival takes place the first Saturday of every October. "Freedom Fest" consists of a parade and a local car show, quoted as being "not too shabby" from a KMOV News reporter, and many other regular carnival events. The "Freedom Fest" was reported to have an attendance of 7,069 as of 2007.