Trade names Eminase Biological half-life 90 minutes DrugBank DB00029 CAS ID 81669-57-0 | ATC code B01AD03 (WHO) CAS Number 81669-57-0 Molar mass 131 million g/mol | |
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Anistreplase is a thrombolytic drug.
Anistreplase has been developed by Beecham as Eminase. It is also known as anisoylated plasminogen streptokinase activator complex (APSAC)
Mechanism
It is a complex of purified human plasminogen and bacterial streptokinase that has been acylated to protect the enzyme's active site. When the drug is administered, the acyl group gets hydrolyzed, thereby freeing the activator complex. It converts plasminogen to plasmin, which in turn degrades fibrin (blood clots) to fibrin split products.
References
Anistreplase Wikipedia(Text) CC BY-SA