Ampatuan is a surname. Notable people with the surname include:
Andal Ampatuan Sr., former Governor of Maguindanao province, the Philippines, and co-suspect in the Maguindanao massacreAndal Ampatuan Jr., former Mayor of Datu Unsay, Maguindanao province, and primary suspect in the Maguindanao MassacreZaldy Ampatuan, former Governor of the Autonomous Region of Muslim Mindanao (ARMM) in the Philippines