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Amorpha 4,11 diene 12 monooxygenase

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EC number
  
1.14.13.158

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

MetaCyc
  
metabolic pathway

Amorpha-4,11-diene 12-monooxygenase (EC 1.14.13.158, CYP71AV1) is an enzyme with systematic name amorpha-4,11-diene,NADPH:oxygen oxidoreductase (12-hydroxylating). This enzyme catalyses the following chemical reaction

amorpha-4,11-diene + 3 O2 + 3 NADPH + 3 H+ ⇌ artemisinate + 3 NADP+ + 4 H2O (overall reaction) (1a) amorpha-4,11-diene + O2 + NADPH + H+ ⇌ artemisinic alcohol + NADP+ + H2O (1b) artemisinic alcohol + O2 + NADPH + H+ ⇌ artemisinic aldehyde + NADP+ + 2 H2O (1c) artemisinic aldehyde + O2 + NADPH + H+ ⇌ artemisinate + NADP+ + H2O

Amorpha-4,11-diene 12-monooxygenase is a heme-thiolate protein (P-450)

References

Amorpha-4,11-diene 12-monooxygenase Wikipedia
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