Samiksha Jaiswal (Editor)

Aminoglycoside N6' acetyltransferase

Updated on
Edit
Like
Comment
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit
EC number
  
2.3.1.82

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

CAS number
  
56467-65-3

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

In enzymology, an aminoglycoside N6'-acetyltransferase (EC 2.3.1.82) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + kanamycin-B CoA + N6'-acetylkanamycin-B

Thus, the two substrates of this enzyme are acetyl-CoA and kanamycin B, whereas its two products are CoA and N6'-acetylkanamycin-B.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:kanamycin-B N6'-acetyltransferase. Other names in common use include aminoglycoside 6'-N-acetyltransferase, aminoglycoside-6'-acetyltransferase, aminoglycoside-6-N-acetyltransferase, and kanamycin acetyltransferase.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1S3Z, 1S5K, 1S60, and 2A4N.

References

Aminoglycoside N6'-acetyltransferase Wikipedia