Formula C39H54N10O12S | Molar mass 886.86 g/mol | |
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Appearance Colorless, crystalline solid | ||
Amanullin is a cyclic nonribosomal peptide. It is an amatoxin, all of which are found in several members of the Amanita genus of mushrooms. The oral LD50 of amanullin is approximately 20 mg/kg in mice, however it is non-toxic in humans.
Toxicology
Like other amatoxins, amanullin is an inhibitor of RNA polymerase II. Amanullin has a species dependent and specific attraction to the enzyme RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme, effectively causing cytolysis of hepatocytes (liver cells).
References
Amanullin Wikipedia(Text) CC BY-SA