Alperin is a surname. Notable people with the surname include:
J. L. Alperin (born 1937), American mathematician, co-discoverer of the Alperin–Brauer–Gorenstein theorem
Mikhail Alperin (born 1956), Ukrainian jazz musician
Steve Alperin, American television news producer
Ignacio Alperin Bruvera, Argentine contemporary visual artist, creativity and innovation professor, lawyer and political scientist