Alperin is a surname. Notable people with the surname include:
J. L. Alperin (born 1937), American mathematician, co-discoverer of the Alperin–Brauer–Gorenstein theoremMikhail Alperin (born 1956), Ukrainian jazz musicianSteve Alperin, American television news producerIgnacio Alperin Bruvera, Argentine contemporary visual artist, creativity and innovation professor, lawyer and political scientist