Acireductone synthase

Acireductone synthase (EC 3.1.3.77, E1, E-1 enolase-phosphatase) is an enzyme with systematic name 5-(methylthio)-2,3-dioxopentyl-phosphate phosphohydrolase (isomerizing). This enzyme catalyses the following chemical reaction

5-(methylthio)-2,3-dioxopentyl phosphate + H₂O ⇌ 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate (overall reaction)(1a) 5-(methylthio)-2,3-dioxopentyl phosphate ⇌ 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate (probably spontaneous)(1b) 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate + H₂O ⇌ 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate