Abietadienol hydroxylase

Abieta-7,13-dien-18-ol hydroxylase (EC 1.14.13.109, CYP720B1, PTAO) is an enzyme with systematic name abieta-7,13-dien-18-ol,NADPH:oxygen oxidoreductase (18-hydroxylating). This enzyme catalyses the following chemical reaction

abieta-7,13-dien-18-ol + NADPH + H⁺ + O₂ ⇌ abieta-7,13-dien-18-al + NADP⁺ + 2 H₂O (overall reaction)(1a) abieta-7,13-dien-18-ol + NADPH + H⁺ + O₂ ⇌ abieta-7,13-dien-18,18-diol + + NADP⁺ + H₂O:(1b) abieta-7,13-dien-18,18-diol ⇌ abieta-7,13-dien-18-al + H₂O (spontaneous)

Abietadienol hydroxylase is a heme-thiolate protein (P-450).