External IDs GeneCards: ATXN8OS Human Mouse Ensembl ENSG00000230223 | Species Human Entrez 6315 | |
Aliases ATXN8OS, KLHL1AS, NCRNA00003, SCA8, ATXN8 opposite strand (non-protein coding) | ||
Ataxin 8 opposite strand, also known as ATXN8OS, is a human gene.
Function
SCA8 is an antisense transcript to the KLHL1 gene (homolog to the Drosophila KELCH gene); it does not itself appear to be protein coding. A CTG trinucleotide repeat expansion that is incorporated into the SCA8 but not the KLHL1 transcript causes spinocerebellar ataxia type 8. Presumably the expansion interferes with normal antisense function of this transcript.
References
ATXN8OS Wikipedia(Text) CC BY-SA