Supriya Ghosh (Editor)

ATP6AP1

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Covid-19
Species  Human
Entrez  537
Human  Mouse
Ensembl  ENSG00000071553
ATP6AP1
Aliases  ATP6AP1, 16A, ATP6IP1, ATP6S1, Ac45, CF2, VATPS1, XAP-3, XAP3, ATPase H+ transporting accessory protein 1
External IDs  MGI: 109629 HomoloGene: 914 GeneCards: ATP6AP1

The human gene ATP6AP1 encodes the S1 subunit of the enzyme V-type proton ATPase.

This gene encodes a component of a multisubunit enzyme (1 mDa MW) that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is composed of a cytosolic, V1, (site of the ATP catalytic site) and a transmembrane, V0, domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene is approximately 45 kD and may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules.

References

ATP6AP1 Wikipedia


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