Species Human Entrez 10476 | Human Mouse Ensembl ENSG00000167863 | |
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Aliases ATP5H, ATPQ, ATP synthase, H+ transporting, mitochondrial Fo complex subunit D External IDs MGI: 1918929 HomoloGene: 130552 GeneCards: ATP5H | ||
The human gene ATP5H encodes subunit d of the enzyme mitochondrial ATP synthase.
Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, F0, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The F0 seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the d subunit of the F0 complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. In addition, three pseudogenes are located on chromosomes 9, 12 and 15.