Species Human Entrez 9474 | Human Mouse Ensembl ENSG00000057663 | |
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Aliases ATG5, APG5, APG5-LIKE, APG5L, ASP, hAPG5, autophagy related 5 External IDs MGI: 1277186 HomoloGene: 3566 GeneCards: ATG5 | ||
Autophagy protein 5 is a protein that in humans is encoded by the ATG5 gene. It is an E3 ubiquitin ligase which is necessary for autophagy due to its role in autophagosome elongation. It is activated by ATG7 and forms a complex with ATG12 and ATG16L1. This complex is necessary for LC3-1 conjugation to PE to form LC3-II.
References
ATG5 Wikipedia(Text) CC BY-SA