Puneet Varma

ATG5

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Species  Human
Entrez  9474
Human  Mouse
Ensembl  ENSG00000057663
ATG5
Aliases  ATG5, APG5, APG5-LIKE, APG5L, ASP, hAPG5, autophagy related 5
External IDs  MGI: 1277186 HomoloGene: 3566 GeneCards: ATG5

Autophagy protein 5 is a protein that in humans is encoded by the ATG5 gene. It is an E3 ubiquitin ligase which is necessary for autophagy due to its role in autophagosome elongation. It is activated by ATG7 and forms a complex with ATG12 and ATG16L1. This complex is necessary for LC3-1 conjugation to PE to form LC3-II.

References

ATG5 Wikipedia


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