Girish Mahajan


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Species  Human
Entrez  115201
Human  Mouse
Ensembl  ENSG00000101844
Aliases  ATG4A, APG4A, AUTL2, autophagy related 4A cysteine peptidase
External IDs  MGI: 2147903 HomoloGene: 70873 GeneCards: ATG4A

Cysteine protease ATG4A is an enzyme that in humans is encoded by the ATG4A gene.

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodelling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Transcript variants that encode distinct isoforms have been identified.


ATG4A Wikipedia

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