Girish Mahajan

ASB2

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Species  Human
Entrez  51676
Human  Mouse
Ensembl  n/a
ASB2
Aliases  ASB2, ASB-2, ankyrin repeat and SOCS box containing 2
External IDs  MGI: 1929743 HomoloGene: 69202 GeneCards: ASB2

Ankyrin repeat and SOCS box protein 2 is a protein that in humans is encoded by the ASB2 gene.

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. This gene is induced by all-trans retinoic acid. In myeloid leukemia cells, the expression of this encoded protein has been shown to induce growth inhibition and chromatin condensation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known.

References

ASB2 Wikipedia


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