| ARHGEF6, COOL2, Cool-2, MRX46, PIXA, alpha-PIX, alphaPIX, Rac/Cdc42 guanine nucleotide exchange factor 6|
MGI: 1920591 HomoloGene: 3561 GeneCards: ARHGEF6
Rho guanine nucleotide exchange factor 6 is a protein that, in humans, is encoded by the ARHGEF6 gene.
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that catalyse the exchange of GDP for GTP in some Rho-family small GTPases. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation.