Entrez 23779 | Ensembl ENSG00000241484 | |
External IDs MGI: 1920417 HomoloGene: 23645 GeneCards: ARHGAP8 |
Function
This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. Rare read-through transcripts, containing exons from the PRR5 gene which is located immediately upstream, led to the original description of this gene as encoding a RHOGAP protein containing the proline-rich domains characteristic of PRR5 proteins. Alternatively spliced variants encoding different isoforms have been described.
References
ARHGAP8 Wikipedia(Text) CC BY-SA