Species Human Entrez 8905 | Human Mouse Ensembl ENSG00000182287 | |
Aliases AP1S2, MGC:1902, MRX59, MRXS21, MRXS5, MRXSF, PGS, SIGMA1B, DC22, adaptor related protein complex 1 sigma 2 subunit External IDs MGI: 1889383 HomoloGene: 2908 GeneCards: AP1S2 | ||
AP-1 complex subunit sigma-2 is a protein that in humans is encoded by the AP1S2 gene.
Function
Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as the small subunit of this complex and is a member of the adaptin protein family. Transcript variants utilizing alternative polyadenylation signals exist for this gene.
References
AP1S2 Wikipedia(Text) CC BY-SA