Girish Mahajan

ANTXR1

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Species  Human
Entrez  84168
Human  Mouse
Ensembl  ENSG00000169604
ANTXR1
Aliases  ANTXR1, ATR, GAPO, TEM8, anthrax toxin receptor 1
External IDs  MGI: 1916788 HomoloGene: 12976 GeneCards: ANTXR1

Anthrax toxin receptor 1 is a protein that in humans is encoded by the ANTXR1 gene.

The protein encoded by this gene is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. This protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants have been described.

References

ANTXR1 Wikipedia


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