Supriya Ghosh

AM 919

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CAS Number  164228-46-0
ChemSpider  8916745
Formula  C27H44O4
Molar mass  432.634 g/mol
PubChem CID  10741414
3D model (Jmol)  Interactive image

AM-919 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoid receptor agonist. It is a derivative of HU-210 which has been substituted with a 6β-(3-hydroxypropyl) group. This adds a "southern" aliphatic hydroxyl group to the molecule as seen in the CP-series of nonclassical cannabinoid drugs, and so AM-919 represents a hybrid structure between the classical and nonclassical cannabinoid families.

AM-919 is somewhat less potent than HU-210 itself, but is still a potent agonist at both CB1 and CB2 with moderate selectivity for CB1, with a Ki of 2.2nM at CB1 and 3.4nM at CB2.


AM-919 Wikipedia

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