Puneet Varma

AM 906

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CAS Number  180989-26-8
ChemSpider  8174103
Formula  C23H34O3
Molar mass  358.513 g/mol
PubChem CID  10089808
ChEMBL  CHEMBL127848
3D model (Jmol)  Interactive image
AM-906

AM-906 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoid agonist. It is conformationally restricted by virtue of the double bond on its side chain, leading an increased affinity for and selectivity between CB1 and CB2 receptors. It is a potent and selective agonist for the CB1 cannabinoid receptor, with a Ki of 0.8 nM at CB1 and 9.5 nM at CB2, a selectivity of almost 12x.

The corresponding E or cis isomer is AM-905.

References

AM-906 Wikipedia


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