Puneet Varma

AM 1221

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Legal status  CA: Schedule II
PubChem CID  11604318
UNII  SHC6SNM293
Molar mass  441.521 g/mol
CAS Number  335160-53-7
ChemSpider  26286945
Formula  C27H27N3O3
AM-1221 httpsuploadwikimediaorgwikipediacommonsthu

AM-1221 is a drug that acts as a potent and selective agonist for the cannabinoid receptor CB2, with a Ki of 0.28 nM at CB2 and 52.3 nM at the CB1 receptor, giving it around 180x selectivity for CB2. The 2-methyl and 6-nitro groups on the indole ring both tend to increase CB2 affinity while generally reducing affinity at CB1, explaining the high CB2 selectivity of AM-1221. However, despite this relatively high selectivity for CB2, its CB1 affinity is still too strong to make it useful as a truly selective CB2 agonist, so the related compound AM-1241 is generally preferred for research purposes.

References

AM-1221 Wikipedia


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