Trisha Shetty

AFF3

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Species  Human
Entrez  3899
Human  Mouse
Ensembl  ENSG00000144218
AFF3
Aliases  AFF3, LAF4, MLLT2-like, AF4/FMR2 family member 3
External IDs  MGI: 106927 HomoloGene: 1718 GeneCards: AFF3

AF4/FMR2 family member 3 is a protein that in humans is encoded by the AFF3 gene.

Function

This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.

References

AFF3 Wikipedia


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