Samiksha Jaiswal

AEE788

Updated on
Share on FacebookTweet on TwitterShare on LinkedIn
CAS Number  497839-62-0
IUPHAR/BPS  7643
ChEMBL  CHEMBL587723
Molar mass  440.5832 g/mol
PubChem CID  10297043
ChemSpider  8472511
Formula  C27H32N6
AEE788 httpsuploadwikimediaorgwikipediacommonsthu

Molekyldynamikk aee788


AEE788 is a multitargeted human epidermal receptor (HER) 1/2 and vascular endothelial growth factor receptor (VEGFR) 1/2 receptor family tyrosine kinases inhibitor with IC50 of 2, 6, 77, 59 nM for EGFR, ErbB2, KDR, and Flt-1. In cells, growth factor-induced EGFR and ErbB2 phosphorylation was also efficiently inhibited with IC50s of 11 and 220 nM, respectively. It efficiently inhibited growth factor-induced EGFR and ErbB2 phosphorylation in tumors for >72 h, a phenomenon correlating with the antitumor efficacy of intermittent treatment schedules. It also inhibits VEGF-induced angiogenesis in a murine implant model. It has potential as an anticancer agent targeting deregulated tumor cell proliferation as well as angiogenic parameters.

References

AEE788 Wikipedia


Similar Topics
The 39 Steps (1935 film)
Olivier Auriac
Stanislav Savchenko
Topics