In enzymology, an ADP-specific glucokinase (EC 22.214.171.124) also known as ADP-dependent glucokinase is an enzyme that catalyzes the chemical reaction
ADP + D-glucose
AMP + D-glucose 6-phosphate
Thus, the two substrates of this enzyme are ADP and D-glucose, whereas its two products are AMP and D-glucose 6-phosphate.
This enzyme belongs to the family of transferases, to be specific those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor.
In humans, the ADP-dependent glucokinase is encoded by the ADPGK gene.
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1GC5.