Girish Mahajan

ADK (gene)

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Species  Human
Entrez  132
Human  Mouse
Ensembl  ENSG00000156110
ADK (gene)
Aliases  ADK, Adk, 2310026J05Rik, 5033405D03Rik, AI255373, AI987814, Ak, adenosine kinase
External IDs  MGI: 87930 HomoloGene: 4891 GeneCards: ADK

Adenosine kinase is an enzyme that in humans is encoded by the ADK gene.

Function

This gene encodes adenosine kinase, an abundant enzyme in mammalian tissues. The enzyme catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Alternative splicing results in two transcript variants encoding different isoforms. Both isoforms of the enzyme phosphorylate adenosine with identical kinetics and both require Mg2+ for activity.

References

ADK (gene) Wikipedia


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