Suvarna Garge


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Species  Human
Entrez  9508
Human  Mouse
Ensembl  ENSG00000156140
Aliases  ADAMTS3, ADAMTS-4, ADAM metallopeptidase with thrombospondin type 1 motif 3
External IDs  MGI: 3045353 HomoloGene: 8596 GeneCards: ADAMTS3

A disintegrin and metalloproteinase with thrombospondin motifs 3 is an enzyme that in humans is encoded by the ADAMTS3 gene.

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene is the major procollagen II N-propeptidase. A deficiency of this protein may be responsible for dermatosparaxis, a genetic defect of connective tissues.


ADAMTS3 Wikipedia

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