Species Human Entrez 95 | Human Mouse Ensembl ENSG00000243989 | |
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Aliases ACY1, ACY-1, ACY1D, HEL-S-5, aminoacylase 1 External IDs MGI: 87913 HomoloGene: 110440 GeneCards: ACY1 | ||
Aminoacylase-1 is an enzyme that in humans is encoded by the ACY1 gene.
Function
Aminoacylase-1 is a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. ACY1 has been assigned to chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and ACY1 is the first member of a new family of zinc-binding enzymes.
References
ACY1 Wikipedia(Text) CC BY-SA