Trisha Shetty

ACY1

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Species  Human
Entrez  95
Human  Mouse
Ensembl  ENSG00000243989
ACY1
Aliases  ACY1, ACY-1, ACY1D, HEL-S-5, aminoacylase 1
External IDs  MGI: 87913 HomoloGene: 110440 GeneCards: ACY1

Aminoacylase-1 is an enzyme that in humans is encoded by the ACY1 gene.

Function

Aminoacylase-1 is a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. ACY1 has been assigned to chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and ACY1 is the first member of a new family of zinc-binding enzymes.

References

ACY1 Wikipedia


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