Entrez 130399 | Ensembl ENSG00000123612 | |
Aliases ACVR1C, ACVRLK7, ALK7, activin A receptor type 1C External IDs OMIM: 608981 MGI: 2661081 HomoloGene: 26724 GeneCards: ACVR1C |
The activin A receptor also known as ACVR1C or ALK-7 is a protein that in humans is encoded by the ACVR1C gene. ACVR1C is a type I receptor for the TGFB family of signaling molecules.
ACVR1C transduces signals of Nodal. Nodal binds to ACVR2B and then forms a complex with ACVR1C. These go on to recruit the R-SMADs SMAD2 or SMAD3.
Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD family transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors.
References
ACVR1C Wikipedia(Text) CC BY-SA