Suvarna Garge (Editor)

ACVR1C

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Species
  
Entrez
  
130399

Human
  
Ensembl
  
ENSG00000123612

Aliases
  
ACVR1C, ACVRLK7, ALK7, activin A receptor type 1C

External IDs
  
OMIM: 608981 MGI: 2661081 HomoloGene: 26724 GeneCards: ACVR1C

The activin A receptor also known as ACVR1C or ALK-7 is a protein that in humans is encoded by the ACVR1C gene. ACVR1C is a type I receptor for the TGFB family of signaling molecules.

ACVR1C transduces signals of Nodal. Nodal binds to ACVR2B and then forms a complex with ACVR1C. These go on to recruit the R-SMADs SMAD2 or SMAD3.

Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD family transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors.

References

ACVR1C Wikipedia


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